Conjugated Linoleic Acid (CLA) is a previously unrecognized nutrient that occurs naturally in wide variety of food, and particularly in beef and dairy products. In more than 17 years of research, CLA has been shown to be an anticarcinogen in several animal models, reduce the adverse catabolic effects induced by immune stimulation in rats, mice and chickens, enhance growth performance in rats and inhibit plaque formation in rabbits fed an atherogenic diet at least in part via changes in lipoprotein metabolism. In the last several years, scientists at the University of Wisconsin-Madison and elsewhere have begun to study CLA’s affect on metabolism, energy retention and balance between body fat and lean body mass.

According to a recent scientific paper, CLA inhibits the body's mechanism for storing fat and causes the body to utilize fatty reserves for energy.

CLA has been shown to inhibit lipoprotein lipase, an enzyme which breaks down fat gobules in the blood so that adipocyte (fat cell) uptake, or body fat accumulation, can occur. The inhibitation of lipoprotein lipase results in reduced fat deposition.

CLA also increases hormone-sensitive lipase activity, an enzyme which breaks down fats stored in fat cells on the body. The fatty acids are returned to the blood stream to be used as an energy source for muscle cells. CLA directs the body to use fat reserves for energy.

CLA also has powerful antioxidant properties. In fact, it has been proposed that adding CLA to foods may prevent oxidation and mold growth in the food products.

Four capsules of Tonalin CLA provide the equivalent amount of Conjugated Linoleic Acid (CLA) of approximately 6 pounds of beef, 50 slices of American cheese, or a gallon of ice cream.

For best value and convenience, buy Clarinol CLA Plus. This is a Liquid CLA with Orange Creamsicle flavor. Most encapsulated CLA products contain just 750mg of CLA per 1000mg gelcap so you need to take about 5 of them to match the amount of CLA in a serving of Clarinol CLA Plus. Not only is Clarinol CLA Plus more convenient, but much more economical as well.

Fat Absorption Control System in a Convenient Liquid!

Conjugated linoleic acid (CLA) is a dietary supplement ingredient which is an effective product for reducing body fat and improving body shape. CLA not only helps you to lose body fat more effectively but also boosts your immune defenses.

Unfortunately, an effective dose of CLA has been about 4 to 10 capsules per day depending on the quality of the CLA source and the size of the gelcap. Now a great-tasting liquid version of highly concentrated CLA is available. CLA Plus with Clarinol is a rich source of conjugated linoleic acid, which has been shown to possess a number of health benefits. Just 1/2 a tablespoon per day is all you need to get the full benefits of CLA that have been detailed in study after study.

• CLA has been shown to help your body reduce fat.
• Studies indicate that CLA boosts your immune system.
• CLA occurs naturally in dairy products and vegetable oils and is part of a healthy diet.
• CLA consumption has decreased dramatically over the last 100 years mainly due to the increased use of low-fat foods and changes in the way cattle are fed.

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CLA Plus with Clarinol contains the highest possible concentration of beneficial active CLA fatty acids, which are called isomers. In a range of 1.4 to 6.8 grams per day of these active isomers, CLA provides an optimal daily dosage for fat mass reduction. At least 3.5 grams (3500mg) of CLA per day is recommended by many experts. Most encapsulated CLA products contain just 750mg of CLA per 1000mg gelcap so you need to take about 5 of them to match the amount of CLA in a serving of CLA Plus with Clarinol. Not only is CLA Plus with Clarinol more convenient than a handful of gelcaps, but much more economical as well!

CLA Plus with Clarinol is provided in glyceride form. This form is identical to the CLA which occurs in natural products as vegetable oils, dairy and meat. An additional benefit of the glyceride is that it has a pleasant taste.

CLA has been shown to decrease body fat in many scientific studies to date. Therefore, when used in combination with a sensible diet and moderate exercise, this may result in safe and effective weight loss.

A number of studies in animals and humans indicate that CLA supplementation decreases body fat and increases lean muscle mass. The increase in lean muscle mass is most pronounced in individuals who are exercising regularly, which makes it an ideal aid for maintaining desirable weight after extra pounds have been lost. The impact of CLA on fat metabolism comes from its effect on the interaction between fat storage cells -adipocytes- with skeletal muscle, the principal site where fat is burned to meet the body's energy needs. CLA appears to reduce the adipocytes. At the same time, CLA enhances the breakdown of fat molecules in the skeletal muscle cells, and it may mitigate the breakdown of muscle tissue to provide energy. Thus, fat is burned at a higher rate, while muscle is both fueled and preserved, leading to a reduction in fat and an increase in lean muscle mass.

CLA is a vegetable oil with a unique structure. Following digestion CLA is absorbed and metabolized by the body - as are all types of oils. Studies in animals and humans have shown that if the amount of CLA in the diet is increased this will result in an increase in the CLA levels in the body tissues.

Scientists now believe that CLA may have a unique effect on body fat by many means:

• By blocking the transport mechanism of fat into fat cells. This way the size of these fat cells is reduced, which may lead to an improved body shape.
• By enhancing the activity of an enzyme present in the muscles. By stimulating this enzyme, it helps the body to burn more fat.
• Fat cells in the body may remain smaller and do not mature. This reduces the level of fat in the body.

No more yo-yo dieting!

Furthermore, CLA may put an end to the frustrations of those who find it difficult to keep their weight stable following a weight loss diet. Especially with crash dieting, the yo-yo effect occurs, where weight is put back on shortly after losing it. A study in the US showed the CLA may help reduce this effect. After the dietary period in this study less body fat accumulated in those taking CLA than those who were not.

The History of CLA

In the early eighties a substance isolated from grilled ground beef by Michael W. Pariza and his research team at the University of Wisconsin was found to inhibit the development of tumors in mice. After further study the substance was identified as conjugated linoleic acid (CLA), a derivative of linoleic acid that is found widely in vegetable oils and animal fats.

CLA is a derivative of linoleic acid, an essential fatty acid found in large amounts in our regular diet. The presence of conjugated fatty acids in milk fat was first established over 66 years ago (Booth et al. 1935). Increased UV light absorption pointed to an increase in conjugated fatty acids in milk which was observed after cows were turned out to pasture in the spring. Unfortunately, cow milk does not contain the large amount of CLA today as it once did due to more "economical" feeding methods.

The biological activity of CLA, however, was unknown until Pariza’s discovery, which set off an explosion of research in this area. Extensive research is underway to determine the total health benefit potential of CLA. The increase is research and general interest in CLA has led to commercial production from vegetable oils high in linoleic acid.

The Research

*The information provided is intended solely for informational and educational purpose, and not as medical advice. Please consult a medical or health professional if you have questions about your health.

Since the early eighties there has been a steady stream of publications, which has grown exponentially by the late nineties. CLA research began with the anti-cancer effects of CLA and soon expanded to other areas of human health. Studies are now showing that CLA may have potential in the prevention of a wide range of human medical conditions. Additionally, CLA may enhance the activity of the immune system. A dedicated CLA web site from the University of Wisconsin records all CLA publications, which keeps the CLA scientific community well informed of each others work.

CLA in the Diet

CLA is naturally produced by cattle and is therefore present in milk, beef and dairy products. It is now known that CLA levels in milk increase when cows are fed grass as opposed to cereals. Therefore, it is believed that CLA levels in food were much higher in the past when cattle were fed mainly on grass, whereas today CLA levels are lower due to more economical feeding methods.

There are many surveys published analyzing the CLA content of foods around the world and in addition scientists have estimated consumption data of CLA by humans. Results suggest that CLA intake varies from 160-430 mg of CLA per day. This variation is dependent on a number of factors including dietary choice, age and sex of an individual.

However, intake is much lower than those of scientific studies inducing beneficial health effects. Therefore the research suggests that in order to obtain health benefits reported for CLA we must supplement our daily diet to reach the levels required for optimum effects, supplementation CLA Plus with Clarinol can safely provide.

Where does CLA Plus with Clarinol come from?

The CLA in CLA Plus with Clarinol is produced from vegetable oils. Only natural sunflower and safflower oils are used. CLA Plus with Clarinol is produced in a dedicated plant in Wormerveer, the Netherlands by a team of experts focused on the production of a world class product. CLA Plus with Clarinol meets a strict set of quality and safety standards (including ISO, GMP and HACCP) resulting in the highest quality CLA available.

Research Results The most fascinating bioactivity of Clarinol™ is its effect on the body’s fat to muscle ratio. The following paragraphs describe briefly the studies demonstrating the effects on growth and body composition. Animal studies The body fat reducing effect of CLA has been observed in many animal studies using rats, mice, hamsters, pigs and chickens. Such an effect was not limited to young animals but was also noticed in adults (Chin et al., 1994, Pariza et al., 1996, Albright et al., 1996, Park et al., 1997, Ostrowska et al.,1999, West et al., 1998, Delany et al., 1999, de Deckere et al., 1999). Human Trials A number of human clinical trials have produced a growing body of evidence pointing at the effectiveness of CLA in the control and management of body weight. A small clinical trial of 20 non-obese people showed a 20% reduction in body fat. A subsequent larger scale trial with 80 obese people lasting 6 months demonstrated that those treated with CLA did not regain fat mass to the same extent as those not taking CLA. This suggests that CLA preferentially produces deposition of muscle mass rather than fat mass (Atkinson et al., 1999). In another study 60 overweight or obese volunteers were treated with CLA for 12 weeks. In this study a dose over 3.4g of CLA per day caused a significant reduction in body fat mass (Blankson et al., 2000). Safety parameters analyzed during this study revealed no adverse effects resulting from CLA treatment (Berven et al., 2000). A Medstat research study fed 1.8 grams of CLA per day for 12 weeks to 20 healthy volunteers. A significant reduction in body fat (20%) was obtained during the study for the CLA group, while no effect was seen in the group not taking CLA (Thom et al., 1997). CLA supplementation had no effect on the parameters examined and no adverse effects were observed in a study examining the effect of CLA (different forms) supplementation (3g/d) for 64 days on body composition, immune parameters and related events in 17 adult healthy women. (Zambell et al. 2000, Medina et al., 2000, Kelley et al., 2000). The CLA used in this study contained several isomers of CLA, the two active isomers, c9-t11 CLA and t10-c12 CLA, were diluted to a greater extent than in the previous studies. This may account for the lack of effect in this study. A trial using 24 novice body builders consuming a daily dose of 7.2g of CLA or a placebo for 6 weeks while completing body building exercises (Lowery et al., 1998) was used to investigate the effect of CLA on muscle development. An increase in skin-fold-corrected arm girth, body mass and leg press was seen in the CLA group compared with the placebo. A similar trial investigated 28 days of CLA supplementation (6g/d) in 24 experienced resistance-trained males (Ferreira et al., 1997). Analysis showed that those athletes taking CLA improved their bench press and leg press strength considerably compared with the athletes taking placebos. These studies clearly show the positive effects CLA has on the fat to muscle ratio and the resulting body profile improvement. A well known shortcoming of weight loss diets is the yo-yo effect where the dieters gains most if not all of the weight back in a short time after the diet stops. CLA has been observed to dampen this yo-yo effect considerably.

Clarinol CLA

Kaizen's Clarinol CLA is 1000mg of Clarinol brand sunflower oil. Conjugated Linoleic Acid is a naturally occurring nutrient which scientific studies have shown may accelerate fat loss, increase body mass, and have potent anti-oxidant properties.

Clarinol CLA is a naturally occurring free fatty acid found in some foods in small amounts - mainly in meat and dairy products.

*  Promotes an increase in lean muscle mass
*  Fat loss; not weight loss
*  Can slow the loss of muscle tissue in catabolic conditions
*  Powerful antioxidant
*  Optimal immune stimulating effects and tumor inhibition

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30-0015 Kaizen Clarinol CLA, 1000mg 90 capsules Nutrition Facts Serving Size: 1 Softgel Servings Per Container: 90 Amount Per Serving % Daily Value* Total Calories 9         Calories From Fat 9      Total Fat 1  g 2%    Clarinol CLA Complex (GMO free) 1000  mg   Total CLA (conjugated linoleic acid) 800  mg   CLA Isomers (c-9, t-11 and t-10, c-12)   74%    *Percent Daily Values are based on a 2,000 calorie diet.   Other Ingredients: Gelatin, glycerin, purified water, carob, tocopherols. Recommended Use: As a dietary supplement, take 1-2 softgels 3 times daily with meals. This product contains glycerine which is not a carbohydrate but has 4.32 calories per gram. Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact Kaizen at 1-800-300-4466 The nutrition facts listed above are supplied as a courtesy to our customers. The nutrition facts were current and accurate to the best of our knowledge at the time they were entered. Manufacturers often change formulas or ingredients without notifying us. We do our best to keep them as up to date as possible, however Netrition.com will not be held responsible for any differences between what is listed on our web site and what is listed on the product that you receive. If you need to be 100% certain of the ingredients currently being shipped, we recommend that you call or email our customer service department to check the shelf of current stock.

CLA 1000

Conjugated Linoleic Acid (CLA) is a recently discovered free-fatty acid that may prove to be essential to our diet. Studies show that CLA may play a vital role in reducing body fat and improving muscle tone. Recent pilot studies on humans have shown a 20% reduction in body fat. This double blind, placebo-controlled study looked at the efficacy and tolerability of CLA on human body composition. Scientists have repeatedly demonstrated the effects of this essential supplement on muscle tone and body fat. Researchers at the University of Wisconsin have shown CLA to play a role in shuttling calories towards muscle and away from body fat. This process is known as repartitioning.

HDT uses only Tonalin brand CLA which has been and continues to be the CLA used in research at the University of Wisconsin, Madison, Purdue University and the United States Department of Agriculture.

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Tonalin CLA-1200

Tonalin CLA-1200 (Conjugated Linoleic Acid) is a patented formula. CLA, derived from pure, natural sunflower oil, is an amazing free fatty acid which goes through an exclusive process that helps "partition" the way energy is stored and used in the body. Unlike any product on the market today, CLA holds several patents covering its use in the reduction of body fat and the promotion of lean muscle mass.

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69-0916 Natrol Tonalin CLA-1200 90 softgels Nutrition Facts Serving Size: 1 softgel Servings Per Container: 90 Amount Per Serving % Daily Value* Total Calories 10         Calories From Fat 10      Total Fat 1  g 2%       Saturated Fat 0  g 0%       Polyunsaturated Fat 1  g      Monounsaturated Fat 0  g      Trans Fat 0  g   Tonalin Proprietary Blend Conjugated linoleic acid, oleic acid, palmitic acid, stearic acid, linoleic acid. 1,200  mg   *Percent Daily Values are based on a 2,000 calorie diet. NO yeast, wheat, corn, milk, egg, soy, glutens, artificial colors or flavors, added sugar or starch.   Other Ingredients: Gelatin, Glycerin, Water, Colored with Caramel, mixed tocopherols (as preservative). Recommended Use: Take 1 softgel three times daily with a meal. Warning: Keep out of reach of children. Consult your health care provider prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating. This product is to be used in conjunction with a healthy calorie reduction and exercise program. This product contains glycerine which is not a carbohydrate but has 4.32 calories per gram. Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact Natrol at 1-800-326-1520 The nutrition facts listed above are supplied as a courtesy to our customers. The nutrition facts were current and accurate to the best of our knowledge at the time they were entered. Manufacturers often change formulas or ingredients without notifying us. We do our best to keep them as up to date as possible, however Netrition.com will not be held responsible for any differences between what is listed on our web site and what is listed on the product that you receive. If you need to be 100% certain of the ingredients currently being shipped, we recommend that you call or email our customer service department to check the shelf of current stock.

FREE Get a FREE EAS Dry Fit Shortsleeve Shirt with the online purchase of $100 or more of any EAS products. You will be prompted at Checkout to accept this offer if your order qualifies. Do not add the item to your shopping cart unless you want to purchase it. While supplies last.

CLA

CLA (conjugated linoleic acid) is a naturally occurring nutrient which scientists have discovered exerts a positive effect on protein and fat metabolism.

Controlled scientific studies have shown that supplementing with CLA may favorably affect body composition. Scientists hypothesize that CLA, possibly acting to enhance metabolic activity at the cellular membrane level, may allow those who supplement with CLA, exercise, and follow a healthy lifestyle to lose fat and gain muscle definition faster. EAS introduced CLA to the supplement market in 1996 and was the first company to fund human clinical studies involving this patented dietary supplement.

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CLA

CLA is a naturally occurring free fatty acid that has been shown to improve nutrient usage and promote muscle tone.

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