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AST
Creatine HSC™ from AST Sports Science

How to Pump Over 87% More Muscle Building Creatine into Your Muscles . . . and Bio-Energetically Fuel the Phospho-Creatine Cycle for Sustained and Continual Muscle Growth Over 247% Greater Than Creatine Monohydrate!

AST Sports Science is networking with leading research groups around the world to deliver you state-of-the-art creatine compounds that are more effective, work better and produce results that the cheap creatine supplements can't come close to. Enter...

Creatine HSC™, the Hyper-Saturation Creatine Complex

The Problem . . .

We all know creatine monohydrate works! You take it - you get bigger and you get stronger. You feel good, you feel big, and you feel strong. You can knock out more and more reps with heavier and heavier weights. It's great stuff - at least for the first month or so. Then what happens? Bam! You hit that wall. The weights aren't moving up like they did at first. That pump just doesn't seem quite as full as it use to. You know what I mean. This is called diminished creatine efficacy. It happens to everyone who relies on simple creatine monohydrate for the their creatine saturation needs.

The Solution . . .

One of the fundamental missions at AST Sports Science is to foster a greater understanding into the dynamics of muscle anabolism through nutritional intervention. Creatine HSC™ takes the science of creatine supplementation even further. New Creatine HSC™ is designed to create a more efficient and congruent atmosphere to increase creatine uptake and utilization within the muscle cell by effectively manipulating the intricate metabolic pathways of the phospho-creatine cycle.


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Creatine Muscle Builders

Creatine HSC's scientifically based creatine formula utilizes an advanced substrate understanding to enhance the biological mechanisms of creatine metabolism. Creatine HSC™ maximizes the integration of creatine carrier sub-pathways and bioenergetic mediation to effectively increase muscle cell creatine uptake, retention and creatine/ATP turnover.

Creatine HSC's innovative Hyper-Saturation Creatine Complex incorporates pure HPLC creatine monohydrate with an integrated bio-energetic ATP support system, a dual-phosphate / taurine matrix, unique sodium / creatine mediators and DGC™ (high-glycemic-index dextrorotatory glucose crystals) to help facilitate a desired creatine Hyper-Saturation effect. Through this Hyper-Saturation effect, Creatine HSC™ delivers over 87% more creatine to your muscles than creatine monohydrate alone. And it doesn't stop there . . .
Creatine HSC glass

Integrated ATP Support System

ATP Support System - AST Sports Science is currently researching the bio-energetic complexities of the phospho-creatine cycle in order to gain a better understanding of the co-interactions with relation to creatine / ATP synthesis. These important intermediaries are key to increasing the intensity and duration of creatine's muscle building effects. By providing these essential intermediate substrates, Creatine HSC™ fuels a micro-cellular environment prime for continued creatine/ATP turnover.

This permits creatine's potential as a fuel and a buffer for ATP and as a contributor to cell hyper-hydration, protein accrual and muscular growth. Creatine HSC™ provides the necessary micro-nutrients that take advantage of creatine's site-specific substrate activity. By providing these bio-energetic nutrients responsible for sustained creatine/ATP turnover, Creatine HSC™ delivers continual dynamic muscle performance increases month after month after month.

Sodium-Creatine Mediators

Sodium-Creatine Mediators - Unknown to but a few resourceful researchers, creatine uptake by the muscle cell is sodium dependent - sodium is required for proper muscle-creatine delivery and utilization. Providing the proper intra / extra-cellular creatine-sodium chemical gradient is crucial to hyper creatine transport - getting more creatine in the muscle than normally allowed under ordinary cellular-metabolic states. Creatine HSC™ stimulates sodium-creatine cotransport by increasing the transmembrane sodium concentration gradient. This increased sodium flow into the cell allows a thermodynamic creatine attatchment to hitch-a-ride in with the sodium. Creatine HSC™ provides a precise sodium requirement to increase cellular creatine accumulation through cross-membrane sodium transport. Another first in the industry.

Dual-Phosphate / Taurine Matrix

Dual-Phosphate / Taurine Matrix - Creatine HSC™ integrates a precise sodium-potassium phosphate combination along with HPLC Taurine for increased muscle cell hydration and insulin-like mediation for creatine transport to promote an optimum cellular medium for accelerated muscle growth. Controlled studies have demonstrated Taurine's potent insulin-like characteristics and have also shown insulin potentiating attributes as well. This dual mimic-potentiate ability may foster an even greater net effect in insulin mediated creatine transport. Numerous studies are indicating the more creatine that can be driven into the muscle cell, the more potential for substantial lean mass accumulation.

Spiking Insulin!

DGC™ - Creatine HSC™ incorporates new high-glycemic-index Dextrorotatory Glucose Crystals. This new glucose component helps mediate a significant increase in creatine uptake and retention by having a sharp impact on serum insulin levels. This insulin spike mediates a hyper uptake of creatine into the muscle cell. DGC provides this insulin medium without the overly sweet sensation other insulin spiking methods produce. Not only does Creatine HSC™ redefine the science of creatine supplementation, but it now provides a refreshing way to do it.

Two Muscle-Quenching Flavors!

New Creatine HSC™ comes in two awesome and refreshing flavors - Juicy Grape and Lemon Squeeze - in 4 pound (41 servings) containers. You just scoop it into a glass, add cold water and stir. Creatine HSC™ mixes instantly into a great tasting, very refreshing and potent muscle-building drink. It doesn't load you down or weigh heavy on your stomach. Creatine HSC™ is simple to use and very effective.

Creatine HSC™ is a breakthrough supplement with a unique precision Hyper-Saturation" formula that integrates the absolute latest in creatine research, delivering you the most scientifically advanced creatine formula available to help you build lean muscle and strength faster. Creatine HSC™ is defining a new era in creatine effectiveness. Creatine HSC™ will change the way you think about fast muscle growth!

Recommended Use: There is a 5 day loading phase: Take 1 serving 4 times a day. After 5 days you reduce your intake to 1 or 2 servings per day.

Servings per container: 41
Serving Size: 1 scoop
Per serving:


References:
1. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996 Nov;271(5 Pt 1): E821-E826

2. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acct Physiol Scand 1996 Oct;158(2): 195-202

3. The utilization of creatine and its analogues by cytosolic and mitochondrial creatine kinase.  Biochim Biophys Acct 1996 Jun 13;1274(3):119-128

4. On the possible pharmacological role of UDP-glucose on some muscular metabolites. Farmaco [Sci] 1984 Mar;39(3):246-254

5. Regulation of Ca2+ transport by insulin and taurine. Interaction at the level of the Na(+)-Ca2+ exchanger. Adv Exp Med Biol. 1996 Jan 1; 403: 551-560

6. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle. J Clin Invest. 1995 Jul 1; 96(1): 370-377

7. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am J Clin Nutr. 1995 May 1; 61(5): 1115-1119

8. Does taurine bind to the insulin binding site of the insulin receptor? Prog Clin Biol Res. 1990 Jan 1; 351: 95-102

9. Insulin-like activity of taurine. Adv Exp Med Biol. 1987 Jan 1; 217: 217-226

10. Potentiation of the actions of insulin by taurine. Can J Physiol Pharmacol. 1983 May 1; 61(5): 457-463

11. Stimulation of muscle protein synthesis by long-term insulin infusion in severely burned patients. Ann Surg. 1995 Sep 1; 222(3): 283-294

12. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest. 1995 Feb 1; 95(2): 811-819

13. Glucose and amino acid transport in human peripheral lymphocytes. Biochem Soc Trans. 1994 Aug 1; 22(3): 269S

14. Effect of insulin on system A amino acid transport in human skeletal muscle. J Clin Invest. 1993 Feb 1; 91(2): 514-521

15. Regulation by insulin of muscle protein metabolism during sepsis and other catabolic conditions. Nutrition. 1992 Nov 1; 8(6): 434-439

16. Characterization of the adenosine receptor modulating insulin action in rat skeletal muscle. Eur J Pharmacol. 1992 Jun 5; 226(2): 121-128

17. Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise. Am J Physiol. 1990 Jan 1; 258(1 Pt 1): E92-E97

18. Effect of hormonal and substrate backgrounds on cell membrane function in normal males. J Appl Physiol. 1987 Sep 1; 63(3): 1107-1113

19. A transient increase in amino acid transport modulated by insulin in differentiating muscle cells. J Cell Physiol. 1979 Feb 1; 98(2): 279-282

20. Signaling elements involved in amino acid transport responses to altered muscle cell volume. FASEB J. 1997 Nov; 11(13): 1111-1117

21. Effects of insulin and exercise on amino acid transport in rat skeletal muscle. Am J Physiol. 1994 Feb 1; 266(2 Pt 1): C524-C530

22. A multichannel transporter for glucose and amino acid transport. Fiziol Zh SSSR Im I M Sechenova. 1992 Aug 1; 78(8): 84-92

23. Amino acid transport System L in muscle cells: biochemical properties and its relation to protein synthesis. Biochim Biophys Acta. 1992 Jul 8; 1108(1): 1-7

24. The regulation of total creatine content in a myoblast cell line. Mol Cell Biochem. 1996 May 24; 158(2): 179-188

25. The cloning and expression of a human creatine transporter. Biochem Biophys Res Commun. 1994 Oct 14; 204(1): 419-427

26. Regulation of intracellular creatine in erythrocytes and myoblasts: influence of uraemia and inhibition of Na,K-ATPase. Cell Biochem Funct. 1994 Jun 1; 12(2): 99-106

 

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