Sublingual Cyclodextrin Complexes
By Patrick Arnold
A clinical study was undertaken recently at
Eastern Michigan University. Mind you, this study has yet to be
published, so I have to be very careful about how I report on the
results here (I can't give absolute numbers at this time, only
percent increases). Otherwise, the researcher may run into
problems getting the study published. Once it's published, however,
the details can and will be released in their entirety.
This particular study examined the acute responses to 25 mg and
50 mg doses of Cyclo-Diol, a 4-androstenediol Sublingual Cyclodextrin Complex (SCC),
in healthy males. These males (the same seven that took part in the original
EMU 4-androstenediol study recently presented in Finland) had
average baseline testosterone concentrations in the high-normal
range. The results, expressed as average percent increases over
baseline, are as follows:
Testosterone Increases With Cyclo-Diol *
Let's examine the results of this study and compare them to the
results that these same seven subjects had a few months earlier
with regular oral 100 mg 4-androstenediol capsules:
Testosterone Increases With Androdiol *
The first thing that strikes the eye is the different times to peak
blood values for the SCC versus the straight oral. The time to peak
is much sooner for the SCC than it is for the straight oral; 40
minutes versus 90 minutes. Also, the percent increase at peak is
much higher for the 25 mg SCC (128%) than it is for the straight
oral (49%). That translates to a 261% greater testosterone
increase with the SCC over straight oral at one quarter the dosage!
As you can see, the dropoff in the T levels for the 25 mg SCC is
quite gradual. Testosterone increases at two hours post-dose were
still well above the peak levels experienced with the straight oral
100 mg dosage.
One of the most intriguing findings from this study was that a 50 mg
dose was no more effective than a 25 mg dose. From talking to
other experts in the field, I've come to believe that this is likely due
to the limited capacity for absorption through the sublingual tissues.
There's only so much surface area under your tongue. The
expression, "trying to stuff ten pounds of potatoes in a five-pound
bag" comes to mind.
In fact, we're wondering if a 10 mg dose of Androdiol SCC might be
equally effective as a 25 mg dose, and, in fact, we're examining
that possibility in a new study that's going on right now.
Another note of interest from this study was that the variability of
testosterone responses among subjects taking the Androdiol SCC
was extremely low. This is in contrast to the oral Androdiol study
where some subjects had increases of testosterone over 100%,
while others had increases of barely 25%.
In other words, just about everybody who used SCC experienced
the same remarkable surges in free testosterone, whereas those
that use(d) oral Androdiol experienced across-the-board results.
This leads us to believe that the biggest factor in the variable
responses to prohormones may not have anything to do with
differing levels of conversion enzymes throughout the body, as is
generally assumed. Instead, it looks like it may have more to do
with differing absorption capabilities from the gut and/or the
differing capacity of people's livers for deactivating orally ingested
prohormones upon first pass.
* These data were presented at the International Weightlifting
Conference in Lahti, Finland, Nov. 1998. Study funded and
supported by LPJ Research Inc. and Subtrate Solutions Inc. The
results do not constitute an endorsement of 4-androstenediol by
the author or Eastern Michigan University.
Androdiol is a registered trademark of LPJ Research, Inc.