Sublimiss is a dietary supplement to help relieve stress and frustration for self-confident mood and cheerful outlook.

Mechanism of Action - Sublimiss is an exciting new natural anti-anxiety supplement that has the added value of being non sedating with potential anti-depressant properties. In central nervous system receptor binding assays, the compound found in Sublimiss is bound to several important targets including the serotonin transporter. It does not bind to the benzodiazepine receptors that would cause sedation, yet has the relaxing qualities of the benzodiazepine class of drugs in validated anxiolytic animal models.

Anxiety is being shown to play a significant role in a wide variety of conditions and disease states. Recent work from the National Institute of Health (NIH) and other major research centers has demonstrated that anxiety is a significant contributor to excess body fat, immune dysfunction, cardiovascular disease and other age-related disorders. Pharmaceutical companies with anxiolytic drugs have launched major consumer advertising campaigns that are fueling the awareness of the problems while building a market for products that can be used to treat anxiety and related conditions. Sublimiss contains the first natural ingredient to be specifically targeted to anxiety and will capitalize on the awareness being generated by the pharmaceutical industry.

Human Trials - This amazing new substance in Sublimiss was tested and found to be a safe, effective and rapidacting, non-sedentary dietary supplement helping control occasional mild anxiety or mild depression. Fifty subjects were treated with the main component in Sublimiss for two weeks. The dosage was applied three times daily with the majority of the subjects taking less than the recommended dose. Based on pre-clinical studies the main ingredient in Sublimiss was designed and evaluated against the following concepts, "Helping control occasional mild anxiety or mild depression and the associated symptoms irritability, emotional ups and downs, restlessness, tense muscles, poor sleep and concentration difficulties."

Post trial analysis revealed significant relaxation in 78% of the subjects. Though the product does not cause significant sedation, 74% of the patients experienced a more restful sleep. NO SIGNIFICANT SIDE EFFECTS WERE REPORTED.

Animal Model - The active ingredient model in Sublimiss has been shown as an effective non-sedating anxiolytic in an animal model known as the "Chick Social Separation-stress Procedure." This model has been validated for several well known benzodiazepines. The paper describing this work has been accepted for publication in the Journal of Psychopharmacology highlighting the excellent results. When it is published, we will have more details here.

Safety Studies - An extensive literature review of the chemical constituents plus the parent plant's use for hundreds of years suggests that this material is safe for its intended use. In addition, an acute toxicity study in mice (5g/kg) with 14-day observation revealed no untoward effects except mild diarrhea and slight sedation in female mice. No side effects are expected at the recommended human dosage.