NOW 7-KETO DHEA

7-KETO is a natural metabolite of DHEA that has all of the benefits but none of the side effects associated with DHEA. 7-KETO is trademarked by Humanetics Corporation and may help to support energy production, healthy skin, lean muscle, liver function and other body functions. The high-potency 100 mg capsule is an excellent complement to the popular 25 mg dosage.

The American College of Physicians conducted a clinical trial to study the effects of 7-KETO on body fat. Thirty overweight adults were recruited. Half were given 100 mg of 7-KETO twice daily, the other half a placebo. All subjects did aerobic exercises three times per week for 60 minutes. Body composition was tested at the start of the trial and twice more at the 4- and 8-week marks. The 7-KETO group showed a 1.8% reduction in body fat while the control group lost 0.57% body fat. No side effects were reported. Researchers concluded that 7-KETO may reduce body fat at a dosage of 200 mg per person per day.

DHEA is the most plentiful hormone in the human body, but its production declines with age. As the levels of DHEA decrease, so does this important metabolite, 7-KETO. 7-KETO is a powerful antioxidant that aids fat metabolism and supports the production of lean muscle tissue.

During the aging process, the levels of certain hormones participating in the metabolic process decline. For example, the level of the female hormone estrogen, made by the ovarian glands, is dramatically reduced after menopause. The level of melatonin, a hormone made at the pineal gland, also declines steadily after the age of 40. The levels of dehyroepiandrosterone (DHEA) and its numerous derivatives, manufactured in the adrenal glands, begin to decline after the age of 30 with about a 50% decline by the age of 40 and about 85% decline by the age of 70. On the contrary, the levels for cortisol and aldosterone, steroid hormones also manufactured in the adrenal glands, essentially remain constant throughout the entire lifespan or, in cases of excessive stress and anxiety, increase.

Concurrent with the decline of these hormone levels during the aging process, there occurs a series of detrimental physiological and anatomical effects. These include a substantial reduction in protein biosynthesis leading to a net loss in muscle mass, and reduction in bone tissue regeneration leading to a net loss of bone mass (a serious risk factor for the onset of osteoporosis). Other negative effects include the substantial decline in the basal metabolic rate leading to a net increase in fat tissue accumulation, the decline in many immune system functions, and the increased rate of neurodegeneration leading to memory loss.

Given these observations, many reputable scientists attest to a definitive relationship between the age-associated decline in hormones, such as DHEA, and physiologic and anatomic trends observed during the aging process. These same scientists also affirm that the restoration of the levels of these declining hormones could potentially delay the rate of muscle and bone tissue loss, strengthen the immune system, increase the capacity to burn fat, and increase the expression of neuroprotective properties. However, the ingestion of hormones as dietary supplements must reliably demonstrate safety and efficasy in order to eliminate short term and long term side effects.

DHEA is actually an intermediate in the biosynthesis of testosterone and estrogen taking place in the adrenal glands. In addition to this, DHEA exhibits a range of physiological effects that are not related to sex hormones. In in vivo clinical trials on genetically obese and normal animals, DHEA demonstrated anti-obesity (fat reducing) properties. Other controlled experiments in animals resulted in DHEA reducing serum cholesterol, strengthening the immune system and improving memory functions through the improvement of neuroprotective properties.

In order, however, to provide a definitive structure-function claim or a mechanistic rationale as to how these liver mediated metabolic improvements take place, a receptor (either bound to a membrane or existing on an enzyme) for DHEA must be identified. The nature of the receptor would then allow for an explanation as to how these biochemical effects take place. To date, no such DHEA receptor has been found. Therefore, it may be that some metabolite or derivative of DHEA may be responsible for the aforementioned positive physiologic effects. In addition, numerous controlled experiments in both animal and human subjects have demonstrated that the ingestion of DHEA has resulted in the net increase of the sex hormones testosterone and estrogen. Elevated levels of these sex hormones pose an increased risk for a range of undesirable effects.

Based on the seminal work of Professor Henry Lardy, a Villas Professor Emeritus of the University of Wisconsin at Madison, Department of Biochemistry, over 150 derivatives of DHEA were prepared and assayed for safety and efficasy over a period of 10 years. One of the prerequisite criteria in selecting these derivatives for further testing was for them not to convert to any of the sex hormones, such as testosterone and estrogen. Eventually, these carefully executed studies led to the identification of the DHEA analog named 3-acetyl-7-oxo-dehydroepiandrosterone (trademarked 7-KETO™), which exhibited the highest biochemical efficacy with no measurable toxicological side effects.

One of the effects from the ingestion of 7-KETO™ in a double blind, placebo controlled clinical study in humans was the stimulation of liver thermogenic enzymes, which increase heat production using fat as the primary source of energy. Naturally, this resulted to the reduction of adipose fat tissue when combined with systematic exercise. Analogously executed clinical studies in humans resulted in 7-KETO™ improving immunologic profiles (the various attributes characterizing a healthy immune system) and improving memory-related functions. In all cases, 7-KETO™ was demonstrated to be substantially more efficacious than DHEA without the unwanted, sex hormone related, side effects.

The safety evaluation of 7-KETO™ was based on observations from an extensive array of pre-clinical and clinical safety studies in both humans and animal subjects. In all cases, 7-KETO™ was consistently found to be safe for human consumption as a dietary supplement.

Add To Cart	Item ID	Product	Unit Size	List Price	Our Price	$200+ Orders
Add	153-0015	NOW 7-KETO DHEA, 25 mg	90 capsules	~~$21.99~~	$10.99	$10.44
Add	153-0054	NOW 7-KETO DHEA, 100 mg	60 capsules	~~$39.99~~	$19.99	$18.99
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Customer Reviews

7-KETO DHEA (NOW) - Average rating

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April 26, 2009
Reviewer: Lance in Texas

I'm a bit of a slow loser, even eating under my base calories it's always been a bit hard for me. For the 2 weeks prior to this product I had the typical very slow loss (in terms of appearance). After adding in 2 of these 100mg tabs a day, the loss has become very noticeable and it's obvious to me after only a short time that this product works. I've tried almost everything out there (hydroxycut, lipo-6, anabolics, thyroid enhancers, etc), and this definitely gave me results the fastest. To anybody having a problem losing weight, take 2 of these twice a day, get in a decent workout (I don't even do cardio due to a knee injury), and don't overdo your calories and I guarantee you'll lose weight.

This review is specific to 7-KETO DHEA, 100 mg

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October 08, 2008
Reviewer: Terri in California

7 Keto, for me, Made The Difference of dieting but not taking off weight compared to dieting and the weight came off. I had No problems with it. I got 100 mg twice a day , about twelve hours apart, for one month and then I skipped At Least one month. So far, 7 Keto has given me results every time (not drastically big results, yet results). "Now" has always been a good quality brand. Netrition has a good price on this.

This review is specific to 7-KETO DHEA, 100 mg

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September 07, 2008
Reviewer: Jay in Georgia

Take earlier in the day vs. night if you have any trouble sleeping.

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February 20, 2008
Reviewer: allen in Michigan

I have been using this for over a week now & have noticed an increase in energy, an overall feeling of wellbeing, plus a drop in body fat. My workouts seem a lot better, more focus. I would highly recommend trying this product, if only for a month to see how you feel.

This review is specific to 7-KETO DHEA, 100 mg

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December 27, 2007
Reviewer: A customer in Texas

This is a great product when used in a responsible manner. In the effort to lose weight, eat plenty of salads, drink plenty of water, do not starve yourself, and get plenty of exercise. Eat meat less than salads and vegetables. Eat bread less than anything. Skim milk if any works great. Sherbet for your ice-cream. Well, that is all I did and it has helped me keep a great figure. Try it. It may just help you too. I take 2 2x a day with water.

This review is specific to 7-KETO DHEA, 100 mg

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Nutrition Facts

153-0015
NOW
7-KETO DHEA, 25 mg
90 capsules

Nutrition Facts Serving Size: 3 Vcaps Servings Per Container: 30


		Amount Per Serving		% Daily Value*



	7-KETO (DHEA Acetate-7-one)	75	mg


*Percent Daily Values are based on a 2,000 calorie diet.

Contains no sugar, salt, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives. Vegetarian formula.


Other Ingredients: Rice flour, vegetable poltsaccharides (capsule), and magnesium stearate (vegetable source).

Recommended Use: As a dietary supplement, take 3 capsule 3 times daily, preferably with meals.

Warning: Please keep out of the reach of children. Recommended to be taken after consulting with your health care practitioner.

Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.


If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact NOW at 1-888-NOW-FOOD

References:

1.Barrett-Conner E, Khaw K-T, Yen SSC. A prospective study of dehyroepiandrosterone-sulfate, mortality and cardiovascular disease. N. Engl. J. Med. 1986, 315, 1519-1524.

2.Ben-Natham D, Kobiler D, Feuerstein G, Lustig S. Anti-stress of dehyroepiandrosterone (DHEA) on mice inoculated with attenuated arboviruses. Prog. NeuroEndocrin. Immunol. 1992, 5, 229.

3.Boumpas DT, Paliogianni F, Anastassiou ED, Balow JE. Glucocorticosteroid action on the immune system: molecular and cellular aspects. Clin. Exp. Rheumatoid. 1991, 9, 413.

4.Cassen PR, Anderson RN, Herrod HG, Stentz FB, Sraughn AB, Abraham GE, Buster JE. Oral dehyroepiandrosterone in physiologic dose modulates immune function in postmenopausal women. Am. J. Obstet. Gynecol. 1993, 1536-1539.

5.Coleman DL. Therapeutic effects of dehyroepiandrosterone (DHEA) and its metabolites in obese hyperglycemic mutant mice. Proc. Clin. Biol. Res.1982, 265, 161-165.

6.Daynes RA, Dudley DI, Araneo BA. Regulation of murine lymphokine production in vivo: II. Dehyroepiandrosterone is a natural enhancer of IL-2 synthesis by helper T-cells. Eur. J. Immunol. 1990, 20, 703-802.

7.Fukushima D, Kemp AD, Schneider, Stokem MB, Gallagher TF. Studies in steroid metabolism. XXV. Isolation and characterization of new urinary steroids. J. Biol. Chem. 1954, 210, 129-137.

8.Kalimi M, Regelson W. eds. The Biological Role of Dehyroepiandrosterone. Walter de Gruyter, New York, 1990.

9.Lardy H, Stratman F, eds. Hormones, Thermogenesis and Obesity. Elsevier, New York, 1989.

10.Lardy H, Partridge B, Kneer N, Wei Y. Ergosteroids: Induction of Thermogenic Enzymes in Liver of Rats Treated with Steroids Derived from Dehyroepiandrosterone. PNAS 1995, 92, 6617-6619.

11.Loria RM, Regelson W, Padgett DA. Immune Response Facilitation and Resistance to Virus and Bacterial Infections with Dehyroepiandrosterone (DHEA). In The Biological Role of Dehyroepiandrosterone Kalimi M, Regelson W. eds. Walter de Gruyter, New York, 1990.

12.Lardy H, Henwood S, Weeks C, An Escalating Dose Oral Gavage Study of 3B-Acetoxyandrost-5-ene-7, 17-dione (7-oxo-DHEA-acetate) in Rhesus Monkeys. Biochemical and Biophysical Research Communications 1999, 254, 124-126.

13.Lardy H, Partridge B, Kneer N, Wei Y. Ergosteroids II. Biologically Active Metabolites and Synthetic Derivatives of Dehyroepiandrosterone. Steroids. 1998, 63, 158-1