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CLA Plus with Clarinol PBL
CLA Plus with Clarinol

Fat Absorption Control System in a Convenient Liquid!

Conjugated linoleic acid (CLA) is a dietary supplement ingredient which is an effective product for reducing body fat and improving body shape. CLA not only helps you to lose body fat more effectively but also boosts your immune defenses.

Unfortunately, an effective dose of CLA has been about 4 to 10 capsules per day depending on the quality of the CLA source and the size of the gelcap. Now a great-tasting liquid version of highly concentrated CLA is available. CLA Plus with Clarinol is a rich source of conjugated linoleic acid, which has been shown to possess a number of health benefits. Just 1/2 a tablespoon per day is all you need to get the full benefits of CLA that have been detailed in study after study.

• CLA has been shown to help your body reduce fat.
• Studies indicate that CLA boosts your immune system.
• CLA occurs naturally in dairy products and vegetable oils and is part of a healthy diet.
• CLA consumption has decreased dramatically over the last 100 years mainly due to the increased use of low-fat foods and changes in the way cattle are fed.


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Antioxidants CLA Diet and Weight Loss Oils/EFAs

CLA Plus with Clarinol contains the highest possible concentration of beneficial active CLA fatty acids, which are called isomers. In a range of 1.4 to 6.8 grams per day of these active isomers, CLA provides an optimal daily dosage for fat mass reduction. At least 3.5 grams (3500mg) of CLA per day is recommended by many experts. Most encapsulated CLA products contain just 750mg of CLA per 1000mg gelcap so you need to take about 5 of them to match the amount of CLA in a serving of CLA Plus with Clarinol. Not only is CLA Plus with Clarinol more convenient than a handful of gelcaps, but much more economical as well!

CLA Plus with Clarinol is provided in glyceride form. This form is identical to the CLA which occurs in natural products as vegetable oils, dairy and meat. An additional benefit of the glyceride is that it has a pleasant taste.

CLA has been shown to decrease body fat in many scientific studies to date. Therefore, when used in combination with a sensible diet and moderate exercise, this may result in safe and effective weight loss.

A number of studies in animals and humans indicate that CLA supplementation decreases body fat and increases lean muscle mass. The increase in lean muscle mass is most pronounced in individuals who are exercising regularly, which makes it an ideal aid for maintaining desirable weight after extra pounds have been lost. The impact of CLA on fat metabolism comes from its effect on the interaction between fat storage cells -adipocytes- with skeletal muscle, the principal site where fat is burned to meet the body's energy needs. CLA appears to reduce the adipocytes. At the same time, CLA enhances the breakdown of fat molecules in the skeletal muscle cells, and it may mitigate the breakdown of muscle tissue to provide energy. Thus, fat is burned at a higher rate, while muscle is both fueled and preserved, leading to a reduction in fat and an increase in lean muscle mass.

CLA is a vegetable oil with a unique structure. Following digestion CLA is absorbed and metabolized by the body - as are all types of oils. Studies in animals and humans have shown that if the amount of CLA in the diet is increased this will result in an increase in the CLA levels in the body tissues.

CLA

Scientists now believe that CLA may have a unique effect on body fat by many means:

  • By blocking the transport mechanism of fat into fat cells. This way the size of these fat cells is reduced, which may lead to an improved body shape.
  • By enhancing the activity of an enzyme present in the muscles. By stimulating this enzyme, it helps the body to burn more fat.
  • Fat cells in the body may remain smaller and do not mature. This reduces the level of fat in the body.

No more yo-yo dieting!

Furthermore, CLA may put an end to the frustrations of those who find it difficult to keep their weight stable following a weight loss diet. Especially with crash dieting, the yo-yo effect occurs, where weight is put back on shortly after losing it. A study in the US showed the CLA may help reduce this effect. After the dietary period in this study less body fat accumulated in those taking CLA than those who were not.

The History of CLA

In the early eighties a substance isolated from grilled ground beef by Michael W. Pariza and his research team at the University of Wisconsin was found to inhibit the development of tumors in mice. After further study the substance was identified as conjugated linoleic acid (CLA), a derivative of linoleic acid that is found widely in vegetable oils and animal fats.

CLA is a derivative of linoleic acid, an essential fatty acid found in large amounts in our regular diet. The presence of conjugated fatty acids in milk fat was first established over 66 years ago (Booth et al. 1935). Increased UV light absorption pointed to an increase in conjugated fatty acids in milk which was observed after cows were turned out to pasture in the spring. Unfortunately, cow milk does not contain the large amount of CLA today as it once did due to more "economical" feeding methods.

The biological activity of CLA, however, was unknown until Pariza’s discovery, which set off an explosion of research in this area. Extensive research is underway to determine the total health benefit potential of CLA. The increase is research and general interest in CLA has led to commercial production from vegetable oils high in linoleic acid.

The Research

*The information provided is intended solely for informational and educational purpose, and not as medical advice. Please consult a medical or health professional if you have questions about your health.

Since the early eighties there has been a steady stream of publications, which has grown exponentially by the late nineties. CLA research began with the anti-cancer effects of CLA and soon expanded to other areas of human health. Studies are now showing that CLA may have potential in the prevention of a wide range of human medical conditions. Additionally, CLA may enhance the activity of the immune system. A dedicated CLA web site from the University of Wisconsin records all CLA publications, which keeps the CLA scientific community well informed of each others work.

CLA in the Diet

CLA is naturally produced by cattle and is therefore present in milk, beef and dairy products. It is now known that CLA levels in milk increase when cows are fed grass as opposed to cereals. Therefore, it is believed that CLA levels in food were much higher in the past when cattle were fed mainly on grass, whereas today CLA levels are lower due to more economical feeding methods.

There are many surveys published analyzing the CLA content of foods around the world and in addition scientists have estimated consumption data of CLA by humans. Results suggest that CLA intake varies from 160-430 mg of CLA per day. This variation is dependent on a number of factors including dietary choice, age and sex of an individual.

However, intake is much lower than those of scientific studies inducing beneficial health effects. Therefore the research suggests that in order to obtain health benefits reported for CLA we must supplement our daily diet to reach the levels required for optimum effects, supplementation CLA Plus with Clarinol can safely provide.

Where does CLA Plus with Clarinol come from?

The CLA in CLA Plus with Clarinol is produced from vegetable oils. Only natural sunflower and safflower oils are used. CLA Plus with Clarinol is produced in a dedicated plant in Wormerveer, the Netherlands by a team of experts focused on the production of a world class product. CLA Plus with Clarinol meets a strict set of quality and safety standards (including ISO, GMP and HACCP) resulting in the highest quality CLA available.

Research Results

The most fascinating bioactivity of Clarinol™ is its effect on the body’s fat to muscle ratio. The following paragraphs describe briefly the studies demonstrating the effects on growth and body composition.
Animal studies
The body fat reducing effect of CLA has been observed in many animal studies using rats, mice, hamsters, pigs and chickens. Such an effect was not limited to young animals but was also noticed in adults (Chin et al., 1994, Pariza et al., 1996, Albright et al., 1996, Park et al., 1997, Ostrowska et al.,1999, West et al., 1998, Delany et al., 1999, de Deckere et al., 1999).
Human Trials
A number of human clinical trials have produced a growing body of evidence pointing at the effectiveness of CLA in the control and management of body weight.
  1. A small clinical trial of 20 non-obese people showed a 20% reduction in body fat. A subsequent larger scale trial with 80 obese people lasting 6 months demonstrated that those treated with CLA did not regain fat mass to the same extent as those not taking CLA. This suggests that CLA preferentially produces deposition of muscle mass rather than fat mass (Atkinson et al., 1999).

  2. In another study 60 overweight or obese volunteers were treated with CLA for 12 weeks. In this study a dose over 3.4g of CLA per day caused a significant reduction in body fat mass (Blankson et al., 2000). Safety parameters analyzed during this study revealed no adverse effects resulting from CLA treatment (Berven et al., 2000).

  3. A Medstat research study fed 1.8 grams of CLA per day for 12 weeks to 20 healthy volunteers. A significant reduction in body fat (20%) was obtained during the study for the CLA group, while no effect was seen in the group not taking CLA (Thom et al., 1997).

  4. CLA supplementation had no effect on the parameters examined and no adverse effects were observed in a study examining the effect of CLA (different forms) supplementation (3g/d) for 64 days on body composition, immune parameters and related events in 17 adult healthy women. (Zambell et al. 2000, Medina et al., 2000, Kelley et al., 2000). The CLA used in this study contained several isomers of CLA, the two active isomers, c9-t11 CLA and t10-c12 CLA, were diluted to a greater extent than in the previous studies. This may account for the lack of effect in this study.

  5. A trial using 24 novice body builders consuming a daily dose of 7.2g of CLA or a placebo for 6 weeks while completing body building exercises (Lowery et al., 1998) was used to investigate the effect of CLA on muscle development. An increase in skin-fold-corrected arm girth, body mass and leg press was seen in the CLA group compared with the placebo. A similar trial investigated 28 days of CLA supplementation (6g/d) in 24 experienced resistance-trained males (Ferreira et al., 1997). Analysis showed that those athletes taking CLA improved their bench press and leg press strength considerably compared with the athletes taking placebos.

  6. These studies clearly show the positive effects CLA has on the fat to muscle ratio and the resulting body profile improvement. A well known shortcoming of weight loss diets is the yo-yo effect where the dieters gains most if not all of the weight back in a short time after the diet stops. CLA has been observed to dampen this yo-yo effect considerably.

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