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Scivation

LipidFX

LipidFX

Advanced Fat Burning Matrix

Scivation LipidFX™ is a precise, scientifically advanced blend of Lipolytic Lipids™. Lipolytic Lipids™ are fatty acids that can increase metabolic rate, significantly support appetite control and immune health, help support healthy lipid profiles and insulin levels and promote optimal cardiovascular health. LipidFX™ can also help the body burn fat instead of muscle while in a calorie-deficient state.


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Appetite Suppressant Diet and Weight Loss Fat Burning Green Tea

Scivation LipidFX - Makes Losing Fat Easy
By: Derek Charlebois, Chuck Rudolph and Marc Lobliner—Team Scivation

As anyone who has ever dieted for an extended period time can tell you, the hardest part about dieting is controlling your appetite. There are products on the market today that aim to decrease appetite, such as hoodia, but for most these simply do not work well enough. Losing weight is governed by calories in vs. calories out. If you eat more calories than you burn you are not going to lose weight.

In addition to controlling one’s appetite, bodybuilders and fitness enthusiast must worry about preserving muscle tissue and losing only fat. Nobody wants to work hard to gain muscle only to lose it when dieting to lose weight.

After extensive research, Scivation has created Lipid FX, a supplement that activates PPARalpha causing an increase in fat oxidation, along with decreasing appetite and improving insulin sensitivity. LipidFX is comprised of three fatty acids: Oleoylethanolamide, Stearoylethanolamide, TetradecylThioacetic Acid as well as EGCG. These ingredients have been shown to help:

  • Maximize Fat Burn*
     
  • Support Appetite Control*
     
  • Promote Optimal Cardiovascular Health*


LipidFX—The Future in Fat Loss Has Arrived!

Scivation LipidFX™ is a precise, scientifically advanced blend of Lipolytic Lipids™. Lipolytic Lipids™ are fatty acids that can increase metabolic rate, significantly support appetite control and immune health, help support healthy lipid profiles and insulin levels and promote optimal cardiovascular health. LipidFX™ can also help the body burn fat instead of muscle while in a calorie-deficient state. Here is why LipidFX is perhaps the biggest breakthrough in healthy fat loss to date!


Peroxisome Proliferator-Activated Receptors (PPAR)

The Peroxisome Proliferator-Activated Receptors (PPAR) receptor family is divided into three subgroups: alpha, delta/beta, and gamma. PPARalpha is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (storage of fatty acids).

Fat can be oxidized in the mitochondria and the peroxisomes of cells, the majority of this oxidation occurring in skeletal muscle cells and the liver. PPARalpha activation increases fat oxidation in mitochondria and peroxisomes by increasing the expression of enzymes involved in beta-oxidation of fatty acids [6]. In addition to this, PPARalpha activation increases the number of both peroxisomes and mitochondria. The combination of the increased number of peroxisomes and mitochondria plus the elevation in beta-oxidation of fatty acids increases the rate and capacity at which fat can be burned. The end result is more fat loss. Activation of PPARalpha would be very beneficial for any bodybuilder or fitness enthusiast looking to lose fat or watch their weight.


PhosphoLean™: Oleoylethanolamide (OEA) and EGCG

Oleoylethanolamide (OEA) is an endogenous lipid being investigated as a potential anti-obesity drug. OEA is synthesized in the intestines. Its synthesis is increased with food intake and decreased with fasting. OEA has been shown to have anorexic properties, meaning it decreases food intake. A study done on rats showed that OEA’s ability to decrease appetite did not change plasma levels of various intestinal hormones involved in satiety, such as ghrelin and CCK, showing OEA works independently of these hormones [1].

OEA is also an activator of the Peroxisome Proliferator-Activator Receptor Alpha (PPARalpha) [2]. Activation of PPARalpha by OEA will cause an increase in fat oxidation along with a decrease in fat storage, creating an ideal environment for fat loss. OEA’s ability to decrease appetite and regulate body weight is accomplished by the activation of PPARalpha [5]. Standard OEA has very poor bioavailability so Scivation uses Phospholean, a form of OEA that is protected from destruction in the stomach.

Green tea extract (EGCG) has been a popular supplement for a while, but more and more research is confirming not only its many health benefits, but its ability to promote fat loss. In addition to multiple animal studies showing green tea to lead to fat loss published just this year, a three month double-blind, placebo controlled study on thirty men was published in the January 2005 issue of the American Journal of Clinical Nutrition. Compared to the placebo group, those who ingested catechins (the beneficial compounds in green tea that extracts are standardized for) daily lost more weight and more fat. While the earlier research was more preliminary, this study confirms the ability of green tea to lead to fat loss in humans.

Recent research has also given us a better picture of how green tea leads to fat loss. The more well-known mechanisms are catechol-O-methyl-transferase (COMT) inhibition, decreased dietary fat absorption, and increased levels of some hormones that suppress the appetite. A study published last year suggested yet another mechanism: when given to rats, green tea decreased the activity of glucose transporter 4 (GLUT4) in fat tissue, while increasing GLUT4 activity in muscle tissue. What this means is that fuel was being shunted away from fat and towards muscle. Not only does green tea facilitate weight loss, it can also lead to the preferential loss of fat over muscle. This is a great asset, since maintaining muscle mass is one of the hardest things to do on a diet.

A new study has discovered the phytochemicals in green tea are better used by the body in supplemental form rather than from actual green tea. The main catechin responsible for the thermogenic effect of green tea extract is epigallocatechin gallate (EGCG). Studies show it can increase metabolism by about 4%. That equates to more than 100 extra calories burned per day for most males. EGCG inhibits the enzyme responsible for the degradation of NE. By preventing NE breakdown, its fat burning effect is stronger and lasts longer.


Stearoylethanolamide (SEA)

Stearoylethanolamide (SEA) has been shown to decrease food intake independent of PPAR and without changing hematochemical parameters such as glucose and triglyceride levels or leptin (a hormone involved with satiety) expression [3]. The appetite decreasing effect of SEA was associated with a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. SCD-1 is the rate-limiting enzyme in the biosynthesis of monounsaturated fats and its reduction is believed to lead to increased fatty acid oxidation and decreased lipogenesis in skeletal muscle and the liver [4].


TetradecylThioacetic Acid (TTA)

TetradecylThioacetic Acid (TTA) is another PPARalpha activator [7]. TTA works in conjunction with OEA in increasing the oxidation of fatty acids and decreasing the storage of fatty acids. TTA has been shown to increase insulin sensitivity by increasing hepatic fat oxidation and ketogenesis while draining fatty acids from the blood and extrahepatic tissues. Increased insulin sensitivity means less insulin needs to be secreted to accomplish a given task. This is beneficial while dieting because insulin is anti-lipolytic.


Summary

  • OEA and SEA decrease appetite
    • Consuming less calories leads to fat loss
  • OEA and TTA activate PPARalpha
    • Activation of PPARalpha increase the rate and capacity of fat oxidation
  • The combination of a decreased caloric intake and elevated fatty acid oxidation ensures fat loss success

If you’re interested in not only optimizing your health but also decreasing appetite and enhancing fat loss all while preserving precious lean muscle, LipidFX is the perfect supplement for you!

References:

1. Proulx K, Cota D, Castaneda TR, Tschop MH, D'Alessio DA, Tso P, Woods SC, Seeley RJ. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R729-37.
2. Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005 Jun;48(8):1147-53.
3. Terrazzino S, Berto F, Dalle Carbonare M, Fabris M, Guiotto A, Bernardini D, Leon A. Stearoylethanolamide exerts anorexic effects in mice via down-regulation of liver stearoyl-coenzyme A desaturase-1 mRNA expression. FASEB J. 2004 Oct;18(13):1580-2. Epub 2004 Aug 2.
4. Dobrzyn A, Ntambi JM The role of stearoyl-CoA desaturase in the control of metabolism.
Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):35-41.
5. Fu, J., et al. Oleylethanolamine regulates feeding and body weight through activation of the nuclear receptor PPAR-á. Nature 425, 90-93 (2003)
6. J Agric Food Chem. 2001 May;49(5):2647-51
7. Madsen L, et al. Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. J Lipid Res. 2002 May;43(5):742-50.

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